Agonisti del recettore GLP-1 e rischio di cancro negli adulti con obesità.

IMPORTANCE: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely prescribed for glycemic control in type 2 diabetes and have recently gained popularity for weight management. However, their long-term impact on cancer risk remains uncertain. Understanding this association is crucial for patient safety. OBJECTIVE: To compare the incidence of 14 cancers among adults with obesity prescribed GLP-1RAs vs nonusers. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study followed a target trial emulation design using 2014 to 2024 electronic health record data from OneFlorida+, a multicenter health research network that integrates real-world clinical data from diverse health c