Gel di idrogel binario-amplificato iniettabile sopprime la recidiva post-incompleta ablazione a microonde mediante immunomodulazione metallometabolica integrata.

Hepatocellular carcinoma (HCC) relapse following incomplete microwave ablation (iMWA) represents a formidable clinical challenge. This progression is fueled by residual tumor cells that exhibit cell death resistance and dysregulated fatty acid metabolism, while exploiting a myeloid-derived immunosuppressive microenvironment. To address this limitation, we developed an injectable binary-amplified cascade hydrogel (S/CuCo@HD) that co-delivers CD36 inhibitor sulfosuccinimidyl oleate (SSO) and a copper-cobalt bimetal-organic framework (Cu-Co BMF). Locally administered S/CuCo@HD serves as a reservoir for sustained-release SSO and Cu-Co BMF within tumor cavities post-iMWA, provoking self-reinforce