Lisina lactililazione mediata modifica post-trascrizionale: meccanismi molecolari e esplorazione di bersagli terapeutici nella resistenza ai farmaci nei tumori.

BACKGROUND: Tumour drug resistance remains a major hurdle in cancer treatment, with post-translational modifications (PTMs) playing a pivotal role in this process. Lysine lactylation (Kla), a newly identified PTM, is tightly associated with the Warburg effect, where tumour cells favour glycolysis even under aerobic conditions, resulting in excessive lactate accumulation. As a key substrate for Kla, this surplus lactate leads to markedly elevated Kla levels in tumours. CONTENT AND FOCUS: This review systematically outlines the molecular mechanisms of Kla, including its biochemical definition, enzymatic regulation, metabolic cross-talk and feedback mechanisms within tumour reprogramming. Furt