Confronto dei marcatori di emolisi tra tre sistemi di ablazione di campo pulsato: studio HEMO-PFA.

BACKGROUND: Pulsed field ablation (PFA) has emerged as a novel non-thermal modality for atrial fibrillation (AF) ablation. While hemolysis is a known complication of PFA, comparative data among different systems remain limited. METHODS: We prospectively enrolled 150 consecutive AF patients undergoing ablation with one of three PFA systems: FARAPULSE (FP), PulseSelect (PS), or VARIPULSE (VP) (50 cases each). Perioperative blood samples were collected pre-procedure, immediately post-procedure, and at 24 h. Hemolysis markers (LDH, LD2, indirect bilirubin, haptoglobin) and myocardial injury markers (CK, CK-MB, troponin T) were measured. Procedural characteristics and complications were compared