L'amiloidosi renale dimenticata: ATTR

The main manifestation of wild-type transthyretin amyloidosis (wtATTR) is cardiac disease in the elderly. Kidney involvement is frequently underappreciated and has been dismissed as a functional consequence of heart failure. Amyloidosis chapters and reviews in kidney journals do not mention wtATTR or kidney involvement in wtATTR and clinical trials do not report chronic kidney disease (CKD) as a relevant comorbidity. However, kidney papillary wtATTR deposits have been described. Recent large series of ATTR cardiac amyloidosis, mostly representing wtATTR, report eGFR and albuminuria values consistent with CKD G3-G5 in >50% and with CKD G1-G5 in 70% of participants, making CKD the most common