Malattia delle arterie periferiche nella malattia renale cronica: una comorbilità sottostimata.

Chronic kidney disease (CKD), defined as an estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m2 or the presence of clinical, imaging, or histopathological features of kidney injury over a 3-month period, has been linked to several comorbidities including cardiovascular diseases, such as myocardial infarction, cerebrovascular diseases, renal artery stenosis and peripheral artery disease. A pro-inflammatory and pro-fibrotic state, together with the accumulation of uremic toxins and impaired calcium-phosphorus homeostasis leading to mineral and bone disorders, appear to constitute the underlying pathophysiology of peripheral artery disease in CKD patients. Despite such associati