Malattia di Hirschsprung: esperienza unicentrica con quattro casi e revisione sistematica della letteratura.

INTRODUCTION: Skip lesion aganglionosis is characterized by intestinal aganglionosis interrupted by portions of normally ganglionated bowel that is located in between segments of aganglionosis. Even though this is a well-known entity, only scattered cases have been reported so far. The aim of this manuscript is to present our series of patients and perform a systematic literature review, to offer a critical overview of possible management. PATIENTS AND METHODS: We hereby present a case series of 4 patients diagnosed during the last five years in our Centre in accordance to SCARE guidelines. A systematic review according to PRISMA guidelines was performed to better address this extremely rar