Sindrome metabolica e rischio di cancro al seno: un paradosso dipendente dall'età?

The study by Kimoto et al. investigated the relationship between metabolic syndrome (MetS) and breast cancer incidence in a large Japanese cohort exceeding one million women, revealing an unexpected age-dependent pattern. Both pre-MetS and MetS were associated with a lower incidence of breast cancer, particularly in women younger than 50 years, whereas this association attenuated or reversed after 60 years of age. In our correspondence, we discuss potential biological and methodological explanations for this paradox. We highlight the importance of heterogeneity in MetS definitions (Japanese vs. modified ATP III), the role of menopausal status beyond chronological age, and possible confoundin