Dieta Cetogena e Esercizio Migliorano la Neuropatia Periferica in un Modello di Topo di Sindrome Metabolica.

UNLABELLED: Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health or reversing established PN is less clear. First, in a maintenance paradigm, we tested whether long-term KD could maintain nerve health in mice, as opposed to a Western-style high-fat diet (HFD) that induces MetS PN. Second, in an intervention paradigm of mice with established MetS PN, we compared the efficacy of low-fat standard diet, KD, exercise, and combined KD-exercise intervent