Narcolessia e malattia metabolica: Una sintesi meta-analitica.

Narcolepsy is a chronic neurological disorder marked by sleep-wake dysregulation and an elevated burden of endocrine and metabolic comorbidities. However, evidence on specific metabolic outcomes across narcolepsy subtypes remains heterogeneous. We conducted a systematic review and meta-analysis (PROSPERO CRD42024576070) to primarily quantify the prevalence and risk of metabolic syndrome (MetS) in narcolepsy, with additional cardiometabolic conditions assessed as secondary outcomes. Five databases were searched through April 8, 2025, included 54 studies after screening. Pooled prevalence estimates and odds ratios were derived using random-effects model, with subgroup analyses by narcolepsy ty