Esposizione ai metalli urinari, infiammazione sistemica e rischio di sindrome cardio-reno-metabolica avanzata negli adulti statunitensi.

To examine inflammatory biomarkers as potential mediators in the association between urinary metal exposure and advanced Cardiovascular-Kidney-Metabolic Syndrome (CKM) risk in US adults, and to evaluate urinary metals' association with risk and their predictive value. Analysis included 6249 NHANES participants. Restricted Cubic Spline (RCS) explored dose-response relationships. Multivariable and piecewise logistic regression assessed associations between specific metals and advanced CKM risk at different exposure levels. Receiver Operating Characteristic (ROC) curves evaluated predictive performance. Mediation analysis tested the role of inflammatory biomarkers. Generalized Weighted Quantile