Patofisiologia e farmacoterapia delle complicazioni cardiovascolari nella sindrome metabolica.

Metabolic syndrome (MetS) symbolises a cluster of interrelated risk factors including central obesity, dyslipidemia, insulin resistance and hypertension, those significantly increase the risk of cardiovascular diseases (CVD). Individuals with a MetS have a two- to fourfold greater risk of coronary artery disease, stroke, myocardial infarction, and heart failure. The pathophysiology of cardiovascular complications in MetS is multifactorial, driven by visceral obesity, insulin resistance, atherogenic dyslipidemia, endothelial dysfunction, oxidative stress, low-grade chronic inflammation, and prothrombotic states. They accelerate the vascular stiffness, atherosclerotic and thrombotic cascades,