Associazione di varianti del gene IL-18 con sintomi depressivi e sindrome metabolica in adulti messicani.

Introduction: metabolic syndrome (MS) affects approximately 27 % of the global population and represents a growing public health concern. Identifying factors associated with its presence is essential for prevention, early diagnosis, and clinical management. Objective: to evaluate the association between depressive symptomatology (DS) and three IL-18 gene variants-rs360719 (-1297 T>C), rs187238 (-137 G>C), and rs1834481 (+488 C>G)-in individuals with MS. Methods: a descriptive, cross-sectional study was conducted between May and June 2023 involving 180 adults (90 with MS and 90 controls), diagnosed according to ALAD criteria. The PHQ-9 questionnaire was used to assess DS. Plasma IL-18 levels