Il legame tra caveole, sindrome metabolica e catarattogenesi: una ipotesi meccanicistica.

Cataract, the leading cause of blindness worldwide, results from progressive lens opacification driven by oxidative stress, protein aggregation, and metabolic dysregulation. Although aging remains the primary risk factor, growing evidence implicates systemic metabolic disorders, particularly metabolic syndrome (MetS), in accelerating cataractogenesis. MetS, characterized by central obesity, hypertension, hyperglycemia, and dyslipidemia, promotes chronic inflammation, oxidative stress, and metabolic imbalance. These systemic disturbances create a biology milieu that lowers the threshold for crystallin oxidation and aggregation, thereby hastening cataract onset and progression. This article pr