Fattori di salute cardiovascolare e paesaggi proteomici alterati nella progressione del sindrome cardiovascolare-rinale-metabolico: evidenze da multi-coorti in Cina, nel Regno Unito e negli Stati Uniti.

BACKGROUND: The role of cardiovascular health (CVH) factors and their associated proteomic profiles in the progression and prognosis of cardiovascular-kidney-metabolic (CKM) syndrome among individuals at stages 0-3 remains unclear. METHODS: This study analyzed data from 10,351 Chinese adults (China Health and Retirement Longitudinal Study [CHARLS]), 224,352 British adults (UK Biobank [UKB]), and 20,726 American adults (National Health and Nutrition Examination Survey [NHANES]). Cox proportional hazards models were used to assess the associations of CVH score and proteomic panel with incident CVD and mortality in CKM stages 0-3 individuals. RESULTS: The median follow-up periods were 13.6 ye