Effetti della sarcopenia obesità sui sintomi depressivi e le loro traiettorie: risultati dal CHARLS 2011-2020.

PURPOSE: Sarcopenia and obesity are recognized factors associated with the onset of depression. Our study aims to clarify the specific impact of sarcopenic obesity on depression development and the longitudinal trajectories of depressive symptoms. METHODS: Data from the 2011-2020 China Health and Retirement Longitudinal Study (CHARLS) were utilized, including 8532 participants aged ≥ 45 years. Cox proportional hazards regression assessed the effect of sarcopenic obesity on the incidence of depression. Restricted cubic spline (RCS) regression explored the relationship between components of sarcopenic obesity (waist circumference, BMI, handgrip strength, and appendicular skeletal muscle mass