Screening della cascata del lipoproteina(a) nella malattia delle arterie coronarie.

BACKGROUND AND AIM: Elevated lipoprotein(a) [Lp(a)] contributes to coronary artery disease (CAD). This study aimed to determine the effectiveness of cascade screening for elevated Lp(a) in patients with CAD. METHODS: Lp(a)-based cascade screening in first-degree relatives (FDR) and second-degree relatives (SDR) of index patients with CAD was performed. Index patients were recruited into pre-defined Lp(a) strata: low (<70 nmol/L), moderately elevated (70-169 nmol/L), and elevated (≥170 nmol/L). Proportions of elevated Lp(a) in relatives were determined within each index stratum, and participation rate was evaluated. RESULTS: 735 index patients (mean age 66.5 years, 76.9% male) participated,