Modelli di crescita e maturazione ossea nei bambini con differenze di sviluppo sessuale dovute a differenze cromosomiche di sesso (45,X/46,XY).

IMPORTANCE: Growth patterns and optimal methods for predicting finale height in individuals with 45,X/46,XY mosaicism remain insufficiently characterized. OBJECTIVE: To assess growth patterns and bone maturations in children with 45,X/46,XY mosaicism and to optimize final height prediction. DESIGN: Multicenter retrospective registry-based cohort study. SETTING: Twenty-six participating centers contributing data. PARTICIPANTS: Ninety-five cases of 45,X/46,XY mosaicism were include. Longitudinal growth data were available for 54 participants and stratified by external genitalia score (EGS): group 1 (EGS 0-4) and group 2 (EGS 4.5-12). INTERVENTION(S) OR EXPOSURE(S): Growth and bone maturat