RPRD1A induce resistenza alla lenvatinib nel carcinoma epatocellulare attraverso l'asse di segnalazione ITGA5-FAK.

Hepatocellular carcinoma (HCC) constitutes a formidable global health challenge. Lenvatinib, a multi-targeted tyrosine kinase inhibitor (TKI), has gradually become a cornerstone therapeutic agent for advanced HCC; however, the emergence of drug resistance severely compromises its clinical efficacy and remains a major obstacle to improving patient outcomes. In this study, we identified key genes associated with lenvatinib resistance, among which regulator of nuclear pre-mRNA domain-containing protein 1A (RPRD1A) emerged as a prominent candidate. Functional assays demonstrated that RPRD1A overexpression significantly reduces the sensitivity of HCC to lenvatinib, whereas its knockdown restores