Efficacia e sicurezza di trattamenti locali combinati con terapia mirata e immunoterapia rispetto alla terapia mirata più immunoterapia sola nel carcinoma epatocellulare: una meta-analisi.

BACKGROUND: Beyond surgical intervention, hepatocellular carcinoma is mainly treated with 3 main approaches: transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) as local treatment, immune checkpoint inhibitors (ICIs), and tyrosine kinase inhibitors (TKIs). Up to now, clinical experts have not reached a consistent consensus on how to reasonably select combination therapy. Therefore, we performed this research to contrast the clinical outcomes of local treatment plus ICIs and TKIs (Local-ICIs-TKIs) with ICIs and TKIs, aiming to offer a practical reference basis for clinical practice. METHODS: We searched the PubMed, Web of Science, Embase, Cochrane Library,