Associazioni congiunte dell'attività fisica misurata con accelerometro e stadi del sindrome cardiovascolare-renale-metabolico con i rischi di cancro e mortalità per tutte le cause.

BACKGROUND: Cardiovascular-kidney-metabolic syndrome clinically increases cancer and mortality risks, but the combined effects of cardiovascular-kidney-metabolic syndrome and physical activity on these outcomes remain poorly understood. METHODS: This prospective study included 66 650 UK Biobank participants with accelerometry data. Cardiovascular-kidney-metabolic syndrome was classified into 5 stages based on metabolic, kidney, and cardiovascular health. Physical activity was categorized by intensity into light, moderate, vigorous, and moderate-to-vigorous levels and further divided into tertiles by daily duration. Multivariable Cox models were used to estimate hazard ratios. RESULTS: Over