Punteggio di rischio poligenico metabolico per la previsione dell'obesità, del diabete di tipo 2 e delle morbidità correlate.

Obesity and type 2 diabetes (T2D) are metabolic diseases with shared pathophysiology. Traditional polygenic risk scores (PRSs) have focused on these conditions individually, yet the single-disease approach falls short in capturing the full dimension of metabolic dysfunction. We derived a biologically enriched metabolic PRS (MetPRS), a composite score that uses multi-ancestry genome-wide association studies of 20 metabolic traits from over 8.5 million individuals. MetPRS, optimized to predict obesity (O-MetPRS) and T2D (D-MetPRS), outperformed existing PRSs in predicting obesity and T2D across six ancestries. O-MetPRS and D-MetPRS effectively identify individuals at high risk for metabolic mu