Meccanismi di epigenesi e rimodellamento del cromosoma nelle cardiomiopatie: una revisione completa.

Cardiomyopathies constitute a heterogeneous group of myocardial disorders representing leading causes of heart failure and cardiovascular mortality worldwide. While genetic mutations have been extensively characterized across different cardiomyopathy subtypes, the mechanistic links between genotype and phenotype remain incompletely understood. This review synthesizes current knowledge regarding chromatin remodeling complexes and their roles in cardiac gene regulation under physiological and pathological conditions. Moreover, disease-specific chromatin remodeling patterns were examined across dilated, hypertrophic, arrhythmogenic, and restrictive cardiomyopathies, highlighting both conserved