Curcuma aumenta la mitofagia via Nrf2-PINK1-mediata, dipendente da Parkin, per sopprimere la ferroptosi nell'insulto cerebrale post-rianimazione.

BACKGROUND: Cardiac arrest (CA) remains a major public health challenge with high incidence and mortality. Post-cardiac arrest brain injury (PCABI) is the primary determinant of poor neurological outcomes and survival. Although curcumin (Cur) exhibits neuroprotective effects in multiple cerebral injury models, its precise pharmacological mechanisms in PCABI remain incompletely understood. PURPOSE: This study aimed to systematically evaluate the therapeutic efficacy of Cur on PCABI and to elucidate its molecular mechanisms, focusing on mitophagy and ferroptosis regulation. METHODS: Neuroprotective effects of Cur were investigated using in vitro oxygen-glucose deprivation/reperfusion and in