Anafilassi grave associata ai farmaci: analisi descrittiva complementare di casi di registro e rapporti spontanei.

PURPOSE: Drugs are among the most common triggers of severe anaphylactic reactions in adults. The aim of our study was to identify the most frequently suspected drugs and associated factors of severe drug-associated anaphylactic reactions in two different data sources. Moreover, the impact of the route of administration (oral versus intravenous) was investigated. METHODS: Severe drug-associated anaphylactic reactions from Germany were analysed in 1046 cases of the European Anaphylaxis Registry and in 1878 spontaneous reports of the European adverse drug reaction (ADR) database EudraVigilance. RESULTS: Several analgesics, antibiotics and contrast media were among others reported most freque