Relazione tra obesità infantile e malattie cardiovascolari e cerebrovascolari: uno studio basato sulla combinazione di più database.

BACKGROUND: The relationship between childhood obesity and cardiovascular and cerebrovascular diseases (CCVD) remains ambiguous. This study aims to explore the causal relationship between childhood obesity and CCVD utilizing the two-sample Mendelian randomization (MR) method. Furthermore, the study investigates the prognostic implications of obesity on CCVD, utilizing insights derived from the Global Burden of Disease (GBD) study 2021. METHODS: This study utilized pooled data on childhood obesity from the genome-wide association study (GWAS) available in the IEU Open GWAS database, alongside data on 20 types of CCVD from the GWAS in the 2024 Finngen database for analysis. The inverse varian