HIV e malattie cardiovascolari: una revisione sistematica e una valutazione del rischio comparativa.

BACKGROUND: People living with HIV (PLWH) face a significantly elevated risk of cardiovascular diseases (CVDs). This study aims to quantify temporal trends in HIV-attributable CVD burden at global, regional and national levels using a comparative risk assessment framework. METHODS: We systematically searched PubMed, Embase and MEDLINE for cohort studies from inception to 28 October 2024, assessing HIV infection and CVD risk. Pooled risk ratios (RRs) for total and subtype-specific CVDs were estimated using random-effects meta-analysis. Based on pooled RRs and HIV prevalence data from the Global Burden of Disease (GBD) 2021 study, we calculated population attributable fractions (PAFs) from 19