Macrofagi associati al tumore con produzione di IL8 e guidati dall'acetato mediano mediatori di immunosoppressione e resistenza all'immunoterapia nel carcinoma renale a cellule chiare.

PURPOSE: Immune checkpoint blockade (ICB) has revolutionized clear-cell renal cell carcinoma (ccRCC) therapy, yet resistance remains common. Tumor-associated macrophages (TAM) shape the tumor-immune interface and contribute to ICB resistance. Although IL8 (CXCL8) was known as a chemokine involved in tumor progression, the role of IL8+ TAMs in ccRCC remains poorly defined. In this study, we aimed to define the clinical and functional relevance of IL8+ TAMs in ccRCC. EXPERIMENTAL DESIGN: Two in-house and four external RCC cohorts, encompassing more than 1,400 patients, were analyzed to determine the clinical relevance of IL8+ TAMs. Immunofluorescence and IHC were applied to quantify IL8+ TAM