Macrofagi associati a lipidi positivi per Stabilin-1 promuovono la metastasi al fegato e la resistenza all'osimertinib nel carcinoma polmonare adenocarcinoma attraverso l'impedimento della fagocitosi dei macrofagi via asse SIRPα-CD47.

AIMS: Lipid-associated macrophages are a specific subpopulation of macrophages that play a crucial role in cancer progression and treatment resistance. However, the functional impact of lipid-associated macrophages in lung adenocarcinoma (LUAD) remains poorly understood. This study aims to investigate the role and underlying mechanisms of lipid-associated macrophages in LUAD liver metastasis and resistance to osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). METHODS: Single-cell RNA sequencing (scRNA-seq) was performed on human lung tumor tissues from patients with primary LUAD and those with LUAD liver metastasis, which identified a nove