Malattia a singolo ventricolo: esiti a lungo termine e morbilità globale nel trial di ricostruzione del singolo ventricolo.

BACKGROUND: In the Single Ventricle Reconstruction (SVR) trial, 1-year transplant-free survival favored the right ventricle-to-pulmonary artery shunt (RVPAS) over the modified Blalock-Taussig-Thomas shunt. However, this benefit diminished over time, and long-term shunt-type comparisons were complicated by the differing morbidity profiles of the 2 shunts. OBJECTIVES: Our objective was to better assess SVR trial global morbidity and longitudinal outcomes by using a novel hierarchically ranked composite endpoint. METHODS: A multi-institutional committee developed the endpoint incorporating death, transplant, parent-reported adaptive function and quality of life, right ventricular function, ma