Prevalenza di Anomalie Cerebrali nei Bambini con Malformazione Congenita del Cuore: Una Revisione Sistemica e Meta-Analisi

CONTEXT: Children with congenital heart disease (CHD) are at risk of cerebral abnormalities. Current evidence is limited by small sample sizes, single-center cohorts, and single time points. OBJECTIVE: Conduct a systematic review and meta-analysis to determine the prevalence of structural cerebral abnormalities on magnetic resonance imaging (MRI) in children with CHD during prenatal, postnatal-preoperative, and postoperative periods. DATA SOURCES: Five electronic databases from inception to August 4, 2025. STUDY SELECTION: Studies published in English in peer-reviewed journals that met the following criteria: 1) samples comprised fetuses from 24 weeks gestation to birth or children from b