L'infezione da virus respiratorio sinciziale dell'infanzia interrompe la rilassazione dell'aria via β2 adrenergica mediante CXCL11 epiteliale.

RATIONALE: Airflow obstruction unresponsive to β2 adrenergic receptor (β2AR) agonists is a key feature of infant respiratory syncytial virus (RSV) bronchiolitis. The underlying mechanisms remain poorly understood, and effective treatment is lacking. OBJECTIVES: To investigate whether and how infant RSV infection affects β2AR signaling in airway smooth muscle cells (ASMCs). METHODS: We established complementary human and mouse models of RSV infection using infant (0-18 months) precision-cut lung slices (PCLSs), neonatal epithelial air-liquid interface (ALI) culture, and mouse pups to assess β2AR-mediated ASMC relaxation. Cytokine profiling was performed using conditioned medium (CM) from RS