Risposte immunitarie innate seguenti l'ischemia e la reperfusion miocardica: Evidenze, meccanismi e sfide traslazionali.

Restoration of coronary blood flow is essential for myocardial salvage in acute myocardial infarction (AMI), yet substantial injury and adverse remodeling often persist after successful reperfusion. Experimental ischemia-reperfusion models have identified dynamic innate immune responses involving neutrophils, monocytes, macrophages, and inflammatory signaling pathways that shape myocardial injury and repair under controlled conditions. In this review, we critically reappraise innate immune activation associated with myocardial ischemia and reperfusion by explicitly distinguishing experimental evidence from immune signatures observed in human myocardial infarction. While experimental studies