La decottazione di Renshen migliora la metabolizzazione energetica miocardica nell'insufficienza cardiaca regolando l'esosoma miR-30e-5p.

BACKGROUND: Abnormal intercellular communication mediated by exosome (EXOs)-miRNAs in cardiac cells is the core pathogenic mechanism that induces myocardial energy metabolism disorders and leads to ventricular remodeling in heart failure (HF). Renshen Decoction (RSD), a traditional formula, exerts significant cardioprotective effects. However, whether it inhibits ventricular remodeling in HF by regulating EXOs-miRNA-mediated intercellular communication remains unclear. OBJECTIVE: To explore the mechanism by which RSD improves myocardial energy metabolism disorders and inhibits ventricular remodeling in HF by regulating EXOs-miRNAs. METHODS: In vivo experiments were conducted to observe the