Consumo di alcol e rischio di fibrillazione atriale: una meta-analisi a coppie e reti.

AIMS: Despite well-established evidence linking alcohol consumption to an increased risk of atrial fibrillation (AF), a clear threshold for safe intake remains undefined. Most clinical guidelines recommend abstinence or moderation, but lack specificity regarding quantitative limits and evidence-based thresholds for primary prevention of AF. METHODS AND RESULTS: We performed this systematic review, pairwise meta-analysis, and network meta-analysis to assess the association and dose-response relationship between varying quantities of alcohol consumption and incident AF. The predefined alcohol intake categories included: no intake, very low (<12 g/day), low (12.1-24 g/day), moderate (24.1-48 g