Terapia antimicrobica empirica e mirata nei pazienti con neutropenia febbrile e malattia ematologica o dopo trapianto di cellule emopoietiche: raccomandazioni dalla 10ª Conferenza europea sulle infezioni nel leucemia.

Febrile neutropenia can lead to life-threatening infections in patients with haematological malignancies or after hematopoietic cell transplantation. Infection management is challenged by rising antibiotic resistance and regional differences in bacterial epidemiology. The 10th European Conference on Infections in Leukaemia panel recommends a personalised approach guided by local resistance patterns and individual risk factors. For patients who are haemodynamically stable without colonisation or infection by resistant Gram-negative bacteria in low-resistance prevalence settings, empirical monotherapy sparing carbapenems or novel β-lactams with or without β-lactamase inhibitors (BLI) is recomm