Immunoprophilassi del virus respiratorio sinciziale: una strategia preventiva sottoutilizzata nei bambini con sindrome di Down.

INTRODUCTION: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection (LRTI) in young children, causing significant morbidity and mortality worldwide. Early life RSV LRTI adversely impacts the developing lung and immune systems, and has been linked to subsequent long-term respiratory sequelae. Children with Down syndrome (DS), with the combined attributes of structural and functional airway anomalies, immune dysregulation, and congenital heart defects are at heightened risk for increased RSV severity and may benefit from passive immunization of RSV immunoprophylaxis. AREAS COVERED: This article reviews the evidence for the burden of RSV LRTI, the subsequent