Toxicità cardiaca indotta dalla clozapina e rechallenge con successo in bambini e adolescenti: una revisione sistematica e nuovo caso di studio.

Treatment-resistant schizophrenia and bipolar disorder represent first-line indications for clozapine prescription in children and adolescents, who display treatment-resistance significantly more often than adults. However, titrating clozapine up to reach an effective dose may become impossible if serious adverse events occur, forcing drug discontinuation. Here we systematically review all articles available in PubMed regarding clozapine-associated cardiac toxicity in children and adolescents, primarily including myocarditis and pericarditis, and focus on the feasibility of clozapine rechallenge after drug discontinuation. Our systematic review identifies 12 articles reporting 13 pediatric c