Rischi poligenici e effetti del trattamento cardiovascolare nella grave malattia mentale.

OBJECTIVE: Patients with severe mental illness (SMI) experience increased cardiovascular risks, leading to reduced life expectancy. Polygenic risk scores (PRS) prediction is promising for assessing cardiovascular risks. This study evaluated the predictive utility of cardiovascular PRS and the impact from risk-reducing interventions among patients with SMI. METHODS: Using samples from the PRIMROSE programme, involving longitudinal cardiovascular interventions within primary care, we calculated seven cardiovascular and two psychiatric (bipolar/schizophrenia) PRS to predict seven corresponding cardiovascular measures [total cholesterol/high-density lipoprotein cholesterol/low-density lipoprote