Come la funzione alterata dell'ippocampo contribuisce allo sviluppo della psicosi?

In this review, we explore the critical role of hippocampal dysfunction in the pathophysiology of psychosis, focusing on translational insights from 22q11.2 deletion syndrome (22q11DS). Converging evidence indicates that individuals with 22q11DS, one of the highest genetic risk factors for schizophrenia, exhibit a shared neurobiological vulnerability with idiopathic psychosis, characterized by cognitive decline and atypical brain development, particularly within the hippocampus. Here, we explore translational evidence for hippocampal dysfunction in humans with 22q11DS and the homologous mouse models at different scales. At the neuronal level, deficits include impaired neural migration, reduc