Coaggregazione familiare e carico genetico condiviso di disturbi mentali e malattie cardiovascolari.

BACKGROUND: The high comorbidity between mental and cardiovascular diseases is widely recognized, but the underlying mechanisms are not yet well understood. We investigated the familial coaggregation and shared genetic loading between these diseases. METHODS: Using claims data from Taiwan's universal health insurance program, we identified cohorts of 4,513,509 individuals with parental information and 3,330,181 with full-sibling information born between 1970 and 1999, and followed up until 2020. Genotyping was available for 106,796 unrelated participants from the Taiwan Biobank. Multiple logistic regression models were used to estimate the association of parental history, full-sibling histo