L'associazione della lacuna di età retinica con la schizofrenia: un'analisi trasversale.

Schizophrenia, a chronic neuropsychiatric disorder increasingly recognized as a multisystemic disease, is associated with accelerated brain ageing. Using deep learning, we investigated the retina, as a window into the central nervous system, as a surrogate of biological ageing in individuals with schizophrenia. This cross-sectional study was nested within AlzEye, a retrospective cohort of individuals aged ≥40 years attending Moorfields Eye Hospital (2008-2018). Retinal age was predicted from color retinal photographs using a convolutional neural network. The difference between predicted retinal age and chronological age, termed the retinal age gap, was estimated in all individuals. Associati