Efficacia e sicurezza delle statine nel diabete di tipo 2 in base al rischio cardiovascolare di base: uno studio di emulazione di trial.

BACKGROUND: Whether statins benefit patients with type 2 diabetes mellitus (T2DM) with low predicted 10-year cardiovascular risk is uncertain. OBJECTIVE: To evaluate the effectiveness and safety of statin initiation for primary prevention among adults with T2DM stratified by predicted 10-year risk for cardiovascular disease (CVD). DESIGN: Cohort study using target trial emulation. SETTING: U.K. primary care using the IQVIA Medical Research Data database. PARTICIPANTS: Persons aged 25 to 84 years with a diagnosis of T2DM between 2005 and 2016 and no history of coronary artery disease, myocardial infarction, stroke, heart failure, myopathy, liver disease, rheumatic heart disease, schizophr