Sicurezza e efficacia delle statine per la prevenzione primaria negli adulti con diabete di tipo 1: un' emulazione.

BACKGROUND: There is no consensus for using statins for primary prevention of cardiovascular disease (CVD) and all-cause mortality in adults with type 1 diabetes mellitus (T1DM), because no randomized controlled trial has exclusively investigated statins in this population. OBJECTIVES: In this study, the authors sought to evaluate the long-term risks and benefits of statins for primary prevention in adults with T1DM. METHODS: We performed a sequential target trial emulation comparing statin initiation vs noninitiation using UK primary care data from the IQVIA Medical Research Data database. Persons aged 25 to 84 years with a diagnosis record of T1DM with prescription of insulin from Januar