Il crosstalk tra complemento, cellule dendritiche e cellule endoteliali nella infiammazione vascolare.

Inflammation is a highly co-ordinated process involving multiple immune components, including the complement system, dendritic cells (DCs), and endothelial cells (ECs). All of them play pivotal roles in immunity and host defence and have a significant impact on cardiovascular health and disease. While individual functions of the complement system, DCs and ECs are well-characterized, their multifaceted interplay in modulating inflammation and disease is insufficiently elucidated. The complement system exerts predominantly pro-inflammatory effects, influencing the immune, cardiovascular, and nervous systems. DCs bridge innate and adaptive immunity, shaping T-cell and B-cell responses depending