Profili proteomici mediante spettrometria di massa utilizzando una libreria spettrale profonda rivelano omogeneizzazione dei proteomi atriale destro e sinistro in pazienti con fibrillazione atriale persistente.

AIMS: Pulmonary veins in the left atrium (LA) are well-established as a critical site for the initiation of atrial fibrillation (AF). Emerging evidence suggests that in persistent AF (persAF), AF triggers may extend beyond LA. However, the extent to which AF-associated remodelling involves the right atrium (RA) in persAF remains a subject of debate. To address this, we employed a proteomic approach aiming at investigating AF-associated remodelling in the RA relative to the LA in persAF. METHODS AND RESULTS: RA and LA samples were obtained from sinus rhythm (SR) patients, patients with persAF undergoing open-heart surgery, and non-failing donor hearts rejected for transplantation. A referenc