Il cinnamaldeide regola il processo EMT e la resistenza ai farmaci nel cancro gastrico attraverso la rimodellazione citoscheletrica mediata da FSTL3.

Cinnamaldehyde (CA) is known to possess anti-tumor properties, such as inhibiting proliferation and migration. However, the specific role and molecular mechanism of CA in gastric cancer (GC) remain unclear. This study aimed to elucidate its effects on GC cell proliferation, migration, epithelial-mesenchymal transition (EMT), and drug resistance, and to explore the potential involvement of follistatin-like 3 (FSTL3) in these processes. The study employed both in vitro and in vivo approaches. In vitro, GC cells were treated with CA to assess its impact on cell proliferation, migration, and EMT. The expression and role of FSTL3 were analyzed. In vivo, the GC xenograft model and intrasplenic inj