Plasticità delle cellule staminali del cancro nella formazione dei paesaggi di resistenza ai farmaci nel cancro prostatico.

BACKGROUND: Prostate-related diseases exhibit an extremely high incidence among aging males, including Benign Prostatic Hyperplasia (BPH) and prostate Cancer (PCa). Prostate stem cells are critical for prostate development, adult tissue homeostasis, and injury repair, and are also considered potential cells of origin for tumorigenesis. Recent studies have demonstrated that various prostate stem cell populations serve as key drivers in both the initiation and progression of prostatic diseases, while also contributing to therapy resistance. Consequently, prostate stem cells have emerged as promising therapeutic targets for both fundamental research and clinical translational studies. AIM OF R