Composti naturali di origine vegetale mirati alla resistenza ai farmaci nel cancro ovarico: meccanismi molecolari e prospettive terapeutiche.

BACKGROUND: Ovarian cancer remains a leading cause of gynecologic cancer-related mortality, primarily driven by the development of multidrug resistance. Plant-derived natural products have gained attention as promising adjuncts to conventional treatments due to their multifaceted mechanisms and low systemic toxicity. PURPOSE: This review summarizes recent advances in plant-derived compounds that counteract ovarian cancer resistance and explores their underlying molecular mechanisms. METHODS: A comprehensive literature search was performed in the PubMed and Web of Science databases to identify English-language articles published up to September 2025. The search terms included "ovarian cance