Gemelli digitali informati elettricamente per la fibrillazione atriale.

Patient-specific digital twins (DTs) are a promising tool for studying cardiac arrhythmias and planning patient-specific therapies. Although recent DTs have begun to incorporate functional data, comprehensive regional calibration of electrophysiological activity during atrial fibrillation (AF) remains a fundamental challenge for improving predictive accuracy. This study presents electrophysiologically-informed DTs (EP-DTs) for atrial fibrillation that integrate detailed patient-specific electrophysiological and anatomical data to emulate the AF electrophysiological phenotype and predict therapy outcomes. Comprehensive EP-DTs of the left atrium (LA) were developed in 12 patients using CT-deri